1、產(chǎn)品物理參數(shù)：
常用名
PD166326
英文名
CAS號
185039-91-2
分子量
427.283
密度
1.5±0.1 g/cm3
沸點
646.3±65.0 °C at 760 mmHg
分子式
C21H16Cl2N4O2
熔點
無資料
閃點
344.7±34.3 °C
PD166326 is one of the most potent members of the pyridopyrimidine class of protein tyrosine kinase inhibitors. In mice with the CML-like disease, PD166326 rapidly inhibited Bcr/Abl kinase activity after a single oral dose and demonstrated marked antileukemic activity in vivo. In vivo, PD166326 was also superior to imatinib mesylate in inhibiting the constitutive tyrosine phosphorylation of numerous leukemia-cell proteins, including the src family member Lyn. PD166326 also prolonged the survival of mice with imatinib mesylate-resistant CML induced by the Bcr/Abl mutants P210/H396P and P210/M351T.
質(zhì)量
426.065033
PSA
80.04000
LogP
3.04
蒸汽壓
0.0±2.0 mmHg at 25°C
折射率
1.706
Pyrido[2,3-d]pyrimidin-7(8H)-one, 6-(2,6-dichlorophenyl)-2-[[3-(hydroxymethyl)phenyl]amino]-8-methyl-
6-(2,6-Dichlorophenyl)-2-{[3-(hydroxymethyl)phenyl]amino}-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one
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