天豐素用途
Epibrassinolide 是一種天然油菜素類固醇(BR)衍生物，是一種植物調節劑，具有與哺乳動物類固醇相似的結構。Epibrassinolide在各種癌細胞中是一種潛在的凋亡誘導劑，而不影響非腫瘤細胞生長。
1、產品物理參數：
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常用名
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天豐素
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英文名
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Epibrassinolide
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CAS號
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78821-43-9
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分子量
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480.677
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密度
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1.1±0.1 g/cm3
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沸點
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633.7±55.0 °C at 760 mmHg
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分子式
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C28H48O6
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熔點
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256°C
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閃點
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202.3±25.0 °C
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2、技術資料：
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體外研究
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表油菜素內酯（EBR）是油菜素類固醇，類固醇衍生植物生長調節劑家族的生物活性化合物。將細胞與各種劑量（0-100μM）的表油菜素內酯一起溫育24或48小時，并通過MTT測定法測定細胞活力。與LNCaP和DU145前列腺癌細胞中的未處理樣品相比，表油菜素內酯以劑量和時間依賴性方式誘導細胞活力喪失。與DU145細胞相比，增加濃度的表油菜素內酯對LNCaP細胞活力喪失更有效，這表明雄**依賴性細胞對表油菜素內酯比對雄**非依賴性前列腺癌細胞更敏感。在進一步的實驗中，選擇25μM的表油菜素內酯，因為其對兩種細胞系具有中等的細胞毒性作用。通過在96小時內計數細胞數來檢查表油菜素內酯治-療對細胞增殖的影響。在LNCaP中觀察到比DU145細胞更高和更早的細胞增殖抑制[1]。
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3、天豐素物理化學性質
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密度
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1.1±0.1 g/cm3
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沸點
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633.7±55.0 °C at 760 mmHg
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熔點
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256°C
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分子式
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C28H48O6
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分子量
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480.677
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閃點
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202.3±25.0 °C
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精-確質量
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480.345093
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PSA
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107.22000
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LogP
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3.12
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蒸汽壓
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0.0±4.2 mmHg at 25°C
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折射率
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1.536
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儲存條件
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?20°C
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4、天豐素英文別名
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CH09964 EPIBRASSINOLIDE
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(3aS,5S,6R,7aR,7bS,9aS,10R,12aS,12bS)-10-[(1S,2R,3R,4S)-2,3-dihydroxy-1,4,5-trimethylhexyl]hexadecahydro-5,6-dihydroxy-7a,9a-dimethyl-3H-benzo[c]indeno[5,4-e]oxepin-3-one
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1,6-Dioxacyclodeca-3,8-dien
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(1R,3aS,3bS,6aS,8S,9R,10aR,10bS,12aS)-1-[(1S,2R,3R,4S)-2,3-dihydroxy-1,4,5-trimethylhexyl]hexadecahydro-8,9-dihydroxy-10a,12a-dimethyl-6H-benz[c]indeno[5,4-e]oxepin-6-one
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24-Epicastasterone
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3.24-EPIBRASSINOLIDE
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(3aS,5S,6R,7aR,7bS,9aS,10R,12aS,12bS)-10-[(2S,3R,4R,5R)-3,4-Dihydroxy-5,6-dimethyl-2-heptanyl]-5,6-dihydroxy-7a,9a-dimethylhexadecahydro-3H-benzo[c]indeno[5,4-e]oxepin-3-one
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(2a,3a,5a,22R,23R,24S)-2,3,22,23-Tetrahydroxy-B-homo-7-oxaergostan-6-one
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(3aS,5S,6R,7aR,7bS,9aS,10R,12aS,12bS)-10-[(2S,3R,4R,5S)-3,4-Dihydroxy-5,6-dimethylheptan-2-yl]-5,6-dihydroxy-7a,9a-dimethylhexadecahydro-3H-benzo[c]indeno[5,4-e]oxepin-3-one
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EPI BRASSINOLIDE
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24-EPIBRASSINOLIDE
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2α,3α,22,23-tetrahydroxy-24-methyl-B-homo-7-oxa-5α-cholestan-6-one
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cis,cis-1,6-Dioxa-3,8-cyclodecadien
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1,6-dioxa-cyclodeca-3,8-diene
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4-Epicastasterone
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(3aS,5S,6R,7aR,7bS,9aS,10R,12aS,12bS)-10-[(2S,3R,4R,5S)-3,4-Dihydroxy-5,6-dimethyl-2-heptanyl]-5,6-dihydroxy-7a,9a-dimethylhexadecahydro-3H-benzo[c]indeno[5,4-e]oxepin-3-one
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(3aS,5S,6R,7aR,7bS,9aS,10R,12aS,12bS)-10-[(2S,3R,4R,5S)-3,4-Dihydroxy-5,6-dimethylheptan-2-yl]-5,6-dihydroxy-7a,9a-dimethylhexadecahydro-3H-benzo[c]indeno[5,4-e]oxepin-3-on
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(2α,3α,5α,22R,23R,24S)-2,3,22,23-Tetrahydroxy-B-homo-7-oxaergostan-6-one
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2a,3a,22,23-Tetrahydroxy-24-methyl-B-homo-7-oxa-5a-cholestan-6-one
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Epibrassinolide(24-Epibrassinolide)
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Brassinolide(epibrassinolide,Homobrassinolide)
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BRASSINOLIDE(BR)
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2,4-Epibrassinolide
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3H-Benz[c]indeno[5,4-e]oxepin-3-one, 10-[(1S,2R,3R,4S)-2,3-dihydroxy-1,4,5-trimethylhexyl]hexadecahydro-5,6-dihydroxy-7a,9a-dimethyl-, (3aS,5S,6R,7aR,7bS,9aS,10R,12aS,12bS)-
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3H-Benz[c]indeno[5,4-e]oxepin-3-one, 10-[(1S,2R,3R,4R)-2,3-dihydroxy-1,4,5-trimethylhexyl]hexadecahydro-5,6-dihydroxy-7a,9a-dimethyl-, (3aS,5S,6R,7aR,7bS,9aS,10R,12aS,12bS)-
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.(22R,23R,24R)-2
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Brassinolide
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Epibrassinolide
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24-(R)-EPIBRASSINOLIDE
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brassinosteroid
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