描述

FG-2216是HIF-PHD抑制劑，IC50值為3.9uM。

相關(guān)類別

信號(hào)通路 >> 代謝酶/蛋白酶 >> HIF/HIF脯氨酰-羥化酶

研究領(lǐng)域 >> 其他

參考文獻(xiàn)

[1]. Hong YR, et al. [(4-Hydroxyl-benzo[4,5]thieno[3,2-c]pyridine-3-carbonyl)-amino]-acetic acid derivatives; HIF prolyl 4-hydroxylase inhibitors as oral erythropoietin secretagogues. Bioorg Med Chem Lett. 2013 Nov 1;23(21):5953-7.

[2]. Hsieh MM, et al. HIF prolyl hydroxylase inhibition results in endogenous erythropoietin induction, erythrocytosis, and modest fetal hemoglobin expression in rhesus macaques. Blood. 2007 Sep 15;110(6):2140-7.