![]()
用途
Lexibulin(CYT-997)是微管蛋白聚集強效抑制劑，對多種癌細胞的IC50值為10-100nM，體外體內具有高效的細胞毒性和血管增生阻斷作用。
1、產品物理參數：
|
常用名
|
N-乙基-N'-[2-甲氧基-4-[5-甲基-4-[[(1S)-1-(3-吡啶基)丁基]氨基]-2-嘧啶基]苯基]脲
|
英文名
|
Lexibulin
|
|
CAS號
|
917111-44-5
|
分子量
|
434.53
|
|
密度
|
1.2±0.1 g/cm3
|
沸點
|
557.7±50.0 °C at 760 mmHg
|
|
分子式
|
C24H30N6O2
|
熔點
|
無資料
|
|
閃點
|
291.1±30.1 °C
|
|
|
2、物理化學性質
|
密度
|
1.2±0.1 g/cm3
|
|
沸點
|
557.7±50.0 °C at 760 mmHg
|
|
分子式
|
C24H30N6O2
|
|
分子量
|
434.53
|
|
閃點
|
291.1±30.1 °C
|
|
PSA
|
107.78000
|
|
LogP
|
4.14
|
|
蒸汽壓
|
0.0±1.5 mmHg at 25°C
|
|
折射率
|
1.610
|
3、英文別名
|
S2195_Selleck
|
|
Lexibulin (USAN)
|
|
CYT997 (Lexibulin)
|
|
Lexibulin
|
|
N-[2-methoxy-4-(6-{[(1S)-1-pyridin-3-ylbutyl]amino}pyrazin-2-yl)phenyl]-N'-ethylurea
|
|
Lexibulin [INN]
|
|
N-ethyl-N'-[2-methoxy-4-(5-methyl-4-{[(1S)-1-pyridin-3-ylbutyl]amino}pyrimidin-2-yl)phenyl]urea
|
|
1-Ethyl-3-[2-methoxy-4-(5-methyl-4-{[(1S)-1-(3-pyridinyl)pentyl]amino}-2-pyrimidinyl)phenyl]urea
|
|
N-ethyl-N'-[2-methoxy-4-[5-methyl-4-[[(1S)-1-(3-pyridinyl)butyl]amino]-2-pyrimidinyl]phenyl]-urea
|
|
N-ethyl-N'-[2-methoxy-4-(5-methyl-4-{[(1S)-1-(pyridin-3-yl)butyl]amino}pyrimidin-2-yl)phenyl]urea
|
|
Lexibulin [USAN:INN]
|
|
CYT997
|
|
(S)-1-ethyl-3-(2-methoxy-4-(5-methyl-4-((1-(pyridin-3-yl)butyl)amino)pyrimidin-2-yl)phenyl)urea
|
|
Urea, N-ethyl-N'-[2-methoxy-4-[5-methyl-4-[[(1S)-1-(3-pyridinyl)pentyl]amino]-2-pyrimidinyl]phenyl]-
|
